Archive for the ‘researches 5’ Category
Wednesday, March 19th, 2008
First Structural Evidence of Actinide-Nitrite Coordination.
The first nitrite complex of actinide metal, {C(NH 2) 3} 2[NpO 2(NO 2)(Pic) 2], was synthesized, and its crystal structure was determined using X-ray diffractometry and confirmed by NIR and IR spectroscopies. Main crystallographic data: space group P1, triclinic, a ...
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Wednesday, March 19th, 2008
Unprecedented Dinuclear Tin Derivative of Deprotonated beta-Cyclodextrins.
Two unprecedented dinuclear tin compounds containing deprotonated beta-cyclodextrins have been constructed by using different organotin and inorganotin precursors under solvothermal conditions, which display two dinuclear airscrew-like structures with different packing modes.
Li SL, Lan YQ, Ma JF, Yang J, Zhang ...
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Wednesday, March 19th, 2008
V4O10: Spectroscopic Fingerprint of a Well-Defined, Molecular Metaloxo Aggregate.
V 4O 10 can be considered as a molecular model for oxovanadium clusters deposited on the surfaces of corresponding heterogeneous catalysts, and here its generation, matrix isolation, and comprehensive characterization by IR, Raman, and UV/vis spectroscopy are ...
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Wednesday, March 19th, 2008
Trithio-Chloro Molybdate [MoClS3](-): A Versatile Precursor for Molybdenum Trisulfido Complexes.
The reaction of trithiomolybdate [PPh 4] 2[MoOS 3] ( 1) with 2 equiv of trimethylchlorosilane generated trithio-chloro molybdate [PPh 4][MoClS 3] ( 2) in high yield, by way of a siloxy complex [PPh 4][Mo(OSiMe 3)S 3] ...
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Wednesday, March 19th, 2008
Molecular Structures of the Digermanes Me2XGeGeXMe2 (X = Me, Cl, and H): An Ab Initio Study Combined with Experimental Investigation by Raman Spectroscopy and Gas Electron Diffraction.
Ab initio calculations were carried out to investigate the potential-energy surface for internal rotation of the methylated digermanes hexamethyldigermane ...
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Wednesday, March 19th, 2008
Similar K@Au10Sn10 Polyhedra in the Markedly Different Structures of KAu4Sn6 and KAu3Sn3. Syntheses and Characterization.
These compounds were synthesized by high-temperature reactions of the elements in welded Ta tubes and characterized by X-ray diffraction methods and linear muffin-tin orbital (LMTO) calculations. AAu 4Sn 6 (A = ...
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Wednesday, March 19th, 2008
Liquid Azide Salts.
Ionic liquid azides from azidoethyl, alkyl, and alkenyl substituted derivatives of 1,2,4- and 1,2,3-amino-triazoles were prepared and examined for the first time to investigate their structural and physical properties. All reported salts possess melting points below 100 degrees C. The unique character of ...
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Wednesday, March 19th, 2008
Ru and Os Complexes Containing a P,N-Donor Heterotopic Ligand: The Effect of Solvent on Stereochemistry.
Ruthenium and osmium complexes of the general formula MCl 2(PyP) 2 (where PyP is the P,N- donor ligand 1-(2-diphenylphosphinoethyl)pyrazole) were synthesized from MCl 2(PPh 3) 3 (where M = Ru or ...
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Wednesday, March 19th, 2008
Helical Supramolecular Assemblies of {2,4,6-[Cp *Rh(E2-1,2-C2B10H10)(NC5H4CH2S)]3(triazine)} (E = S, Se) Shaped by Cp *-Toluene-Cp * pi-Stacking Forces and BH-Pyridine Hydrogen Bonding.
Polycarborane-substituted molecules [Cp *Rh{E 2C 2(B 10H 10)}] 3(tpst) [E = S ( 2a), Se ( 2b)] were synthesized and characterized. 2a and 2b form ...
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Wednesday, March 19th, 2008
Synthesis and Characterization of Luminescent Zinc(II) and Cadmium(II) Complexes with N,S-Chelating Schiff Base Ligands.
The reactions of zinc(II) acetate with a variety of 2-substituted benzothiazolines afforded tetrahedral mononuclear complexes with a N 2S 2 donor set, [Zn(RPhC(H) NC 6H 4 S) 2]. The obtained zinc(II) complexes ...
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Wednesday, March 19th, 2008
New Fluorogenic Dansyl-Containing Calix[4]arene in the Partial Cone Conformation for Highly Sensitive and Selective Recognition of Lead(II).
A new efficient and highly selective fluorescent chemosensor for determination of Pb (2+) has been obtained by covalent attachment of two pendent proton-ionizable dansylcarboxamide groups to the calix[4]arene preorganized ...
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Wednesday, March 19th, 2008
Luminescence and Mesogenic Properties in Crown-Ether-Isocyanide or Carbene Gold(I) Complexes: Luminescence in Solution, in the Solid, in the Mesophase, and in the Isotropic Liquid State.
A crown ether isocyanide CNR (R = benzo-15-crown-5) has been synthesized by dehydration of the corresponding formamide. Substitution reactions with the ...
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Wednesday, March 19th, 2008
Mechanism of Hydride Donor Generation Using a Ru(II) Complex Containing an NAD(+) Model Ligand: Pulse and Steady-State Radiolysis Studies.
The mechanistic pathways of formation of the NADH-like [Ru(bpy) 2(pbnHH)] (2+) species from [Ru(bpy) 2(pbn)] (2+) were studied in an aqueous medium. Formation of the one-electron-reduced species ...
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Wednesday, March 19th, 2008
Overcoming Drug Resistance to Heme-Targeted Antimalarials by Systematic Side Chain Variation of 7-Chloro-4-aminoquinolines.
Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four different strains of P. falciparum. Many ...
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Wednesday, March 19th, 2008
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic beta Cell Protection and Replication.
Recently, the serine/threonine kinase glycogen synthase kinase-3 (GSK-3) emerged as a regulator of pancreatic beta cell growth and survival. On the basis of the previous observation that GSK-3 inhibitors like 1-azakenpaullone ...
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Wednesday, March 19th, 2008
Synthesis and Evaluation of Novel Polyaminocarboxylate-Based Antitumor Agents.
Iron depletion, using iron chelators targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective in the treatment of cancer. We synthesized and evaluated novel polyaminocarboxylate-based chelators NETA, NE3TA, and NE3TA-Bn and their bifunctional versions ...
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Wednesday, March 19th, 2008
Constrained Analogues of Procaine as Novel Small Molecule Inhibitors of DNA Methyltransferase-1.
Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative 3b, was also able to induce a recognizable demethylation of chromosomal satellite repeats ...
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Wednesday, March 19th, 2008
Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration.
Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in the potency and selectivity of the compounds, resulting in ...
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Wednesday, March 19th, 2008
Design and Synthesis of 4-Substituted Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidine Derivatives with Antitumor Activity.
New derivatives of the indolo[3,2- e][1,2,3]triazolo[1,5- a]pyrimidine system, substituted in the 4 position, were designed as novel antitumor agents because of their theoretical capability to form stable complexes with DNA fragments. The calculated free energies of ...
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Wednesday, March 19th, 2008
Proteomic Identification of PKC-Mediated Expression of 20E-Induced Protein in Drosophila melanogaster.
Sun Y, An S, Henrich VC, Sun X, Song Q.
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Wednesday, March 19th, 2008
Identification of Breast Cancer Peptide Epitopes Presented by HLA-A*0201.
Cellular immune mechanisms detect and destroy cancerous and infected cells via the human leukocyte antigen (HLA) class I molecules that present peptides of intracellular origin on the surface of all nucleated cells. The identification of novel, tumor-specific ...
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Wednesday, March 19th, 2008
An (86)Y-Labeled Mirror-Image Oligonucleotide: Influence of Y-DOTA Isomers on the Biodistribution in Rats.
A mirror-image oligonucleotide ( l-RNA) was radiolabeled with the positron emitting radionuclide (86)Y ( t 1/2 = 14.7 h) via the bifunctional chelator approach. DOTA-modification of the l-RNA (sequence: 5\'-aminohexyl UGA CUG ACU ...
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Wednesday, March 19th, 2008
X-ray Crystal Structures, Electron Paramagnetic Resonance, and Magnetic Studies on Strongly Antiferromagnetically Coupled Mixed mu-Hydroxide-mu-N(1),N(2)-Triazole-Bridged One Dimensional Linear Chain Copper(II) Complexes.
Four new metal-organic polymeric complexes, {[Cu(mu-OH)(mu-ClPhtrz)][(H 2O)(BF 4)]} n ( 1), {[Cu(mu-OH)(mu-BrPhtrz)][(H 2O)(BF 4)]} n ( 2), {[Cu(mu-OH)(mu-ClPhtrz)(H 2O)](NO 3)} n ( 3), and {[Cu(mu-OH)(mu-BrPhtrz)(H ...
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Wednesday, March 19th, 2008
Synthesis, NMR and Vibrational Spectroscopic Characterization, and Computational Study of the cis-IO2F3(2-) Anion.
The N(CH 3) 4 (+) salt of the cis-IO 2F 3 (2-) anion was synthesized from [N(CH 3) 4][IO 2F 2] and excess [N(CH 3) 4][F] in CH 3CN solvent. The [N(CH 3) ...
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Wednesday, March 19th, 2008
Arylthiolate Coordination and Reactivity at Pseudotetrahedral Nickel(II) Centers: Modulation by Noncovalent Interactions.
Five new pseudotetrahedral nickel(II) arylthiolate complexes Tp (R,Me)Ni-SR\' [(Tp (R,Me)) (-) = 2,2,2-kappa (3)-hydridotris(3-R,5-methylpyrazolyl)borate; R = Me, R\' = C 6H 5 (Ph), 2,4,6-C 6H 2(CH 3) 3 (Mes); R = Ph, R\' = ...
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