Archive for the ‘researches 5’ Category
Wednesday, March 19th, 2008
High Energy Shock Waves (HESW) Increase Paclitaxel Efficacy in a Syngeneic Model of Breast Cancer.
The combined effect of high energy shock waves (HESW), generated by a piezoelectric device, and paclitaxel on Mat B-III rat breast cancer cells in vitro and in an in vivo animal ...
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Wednesday, March 19th, 2008
Low Generation Polypropylenimine Dendrimer Graft beta-cyclodextrin: An Efficient Vector for Gene Delivery System.
The purpose of this study was to evaluate the characterization of a new cationic vector. Low generation polypropylenimine (DAB-8) was conjugated to beta-cyclodextrin (beta-CyD), and the chemical characters of the vector were investigated ...
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Wednesday, March 19th, 2008
Long-lasting In vivo Gene Silencing by Electrotransfer of shRNA Expressing Plasmid.
RNA interference appears as a promising tool for therapeutic gene silencing. A key limit is the delivery of the siRNA. A safe approach is to use a physical method such as in vivo electropulsation with ...
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Wednesday, March 19th, 2008
Gene Electrotransfer into Murine Skeletal Muscle: A Systematic Analysis of Parameters for Long-term Gene Expression.
Skeletal muscle is an attractive target tissue for delivery of therapeutic genes, since it is well vascularized, easily accessible, and has a high capacity for protein synthesis. For efficient transfection in ...
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Wednesday, March 19th, 2008
Bile Salt-Induced Vesicle-to-Micelle Transition in Catanionic Surfactant Systems: Steric and Electrostatic Interactions.
The vesicle-to-micelle transition (VMT) was realized in catanionic surfactant systems by the addition of two kinds of bile salts, sodium cholate (SC) and sodium deoxycholate (SDC). It was found that steric interaction between the ...
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Wednesday, March 19th, 2008
Quasistatic Computer Simulation Study of the Shear Behavior of Bi- and Trilayer Water Films Confined between Model Hydrophilic Surfaces.
In this paper, our previous simulations of the shear behavior of confined water monolayers (Pertsin, A.; Grunze, M. Langmuir 2008, 24, 135) are extended to water films ...
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Wednesday, March 19th, 2008
Atmospheric Pressure Chemical Ionization Source. 2. Desorption-Ionization for the Direct Analysis of Solid Compounds.
The flowing afterglow-atmospheric pressure glow discharge (APGD) ionization source described in part 1 of this study (in this issue) is applied to the direct analysis of condensed-phase samples. When either liquids or ...
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Wednesday, March 19th, 2008
Atmospheric Pressure Chemical Ionization Source. 1. Ionization of Compounds in the Gas Phase.
A novel chemical ionization source for organic mass spectrometry is introduced. This new source uses a glow discharge in the flowing afterglow mode for the generation of excited species and ions. The direct-current ...
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Wednesday, March 19th, 2008
Organochlorine Pesticides by LC-MS.
Contamination of water resources by organochlorine pesticides (OCPs) continues to receive widespread attention because of the increasing concern regarding their high persistence and bioaccumulation. These organic pollutants are not amenable by liquid chromatography (LC) coupled to atmospheric pressure ionization-mass spectrometry, which represents ...
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Wednesday, March 19th, 2008
Tunable Photochromism of Spirobenzopyran via Selective Metal Ion Coordination: An Efficient Visual and Ratioing Fluorescent Probe for Divalent Copper Ion.
In the present paper, a new spirobenzopyran derivative was synthesized and applied in simultaneously colorimetric and fluorescence ratiometric detections of Cu2+. In contrast to the virtually ...
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Wednesday, March 19th, 2008
Near-Infrared Spectropolarimetry Based on Acousto-Optical Tunable Filters.
A new approach to near-infrared (NIR) spectropolarimetry is described, in which the properties of a noncollinear acousto-optical tunable filter (AOTF) made of an anisotropic crystal of TeO2 is employed to produce a novel instrument that precludes or reduces significantly ...
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Wednesday, March 19th, 2008
Biomimetic Total Synthesis of Malbrancheamide and Malbrancheamide B.
The biomimetic total syntheses of both malbrancheamide and malbrancheamide B are reported. The synthesis of the two monochloro species enabled the structure of malbrancheamide B to be unambiguously assigned. The syntheses each feature an intramolecular Diels-Alder reaction of ...
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Wednesday, March 19th, 2008
Detection of Multiphosphorylated Peptides in LC-MS/MS Analysis under Low pH Conditions.
An improved method of detection of multiphosphorylated peptides by RPLC-MS/MS analysis under low pH conditions (pH approximately 1.7, 3% formic acid) is demonstrated for the model phosphoproteins, bovine alpha- and beta-casein. Changes in the pH ...
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Wednesday, March 19th, 2008
Decarboxylative Isomerization of N-Acyl-2-oxazolidinones to 2-Oxazolines.
N-Acyl-2-oxazolidinones are ring-opened by lithium iodide and decarboxylated in the presence of a mild proton source. Further reaction with an amine base provides 2-oxazolines. The transformation is general for oxazolidinones unsubstituted in the 5 position and occurs under mild conditions ...
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Wednesday, March 19th, 2008
Synthesis of Cyclic Peroxides Containing the Si-gem-bisperoxide Fragment. 1,2,4,5,7,8-Hexaoxa-3-silonanes as a New Class of Peroxides.
A method was developed for the synthesis of the previously unknown class of organic peroxides, 1,2,4,5,7,8-hexaoxa-3-silonanes, based on the reaction of dialkyldichlorosilanes with 1,1\'-dihydroperoxyperoxides. 1,2,4,5,7,8-Hexaoxa-3-silonanes are rather stable under ambient conditions ...
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Wednesday, March 19th, 2008
Radical Fixation of Functionalized Carbon Resources: alpha-sp(3)C-H Carbamoylation of Tertiary Amines with Aryl Isocyanates.
Yoshimitsu T, Matsuda K, Nagaoka H, Tsukamoto K, Tanaka T.
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Wednesday, March 19th, 2008
Synthesis and Testing of 2-Deoxy-2,2-Dihaloglycosides as Mechanism-Based Inhibitors of alpha-Glycosidases.
The synthesis of a series of 2-deoxy-2,2-dihaloglycosyl halides as potential alpha-glycosidase inactivators has been achieved via the halogenation of protected 2-fluoroglycal precursors. Direct chlorination of per-O-acetylated 2-fluoro-d-glucal and 2-fluoromaltal followed by basic deprotection yielded the corresponding ...
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Wednesday, March 19th, 2008
Allenyl Azide Cycloaddition Chemistry. Photochemical Initiation and CuI Mediation Leads to Improved Regioselectivity.
Irradiation of 2-(3-alkenyl)allenylphenyl azides in the presence of excess CuI furnished functionalized 2,3-cyclopentenylindoles in good yield with only trace amounts of competitive C-N-bonded regioisomeric products. These results represent a significant departure from the ...
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Wednesday, March 19th, 2008
Escherichia coli Glucuronylsynthase: An Engineered Enzyme for the Synthesis of beta-Glucuronides.
The glycosynthase derived from E. coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of ...
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Wednesday, March 19th, 2008
Sc(3+)-Catalyzed Aldol-Type Additions of N-Benzoylcyclopropanecarboxamides via Iodide-Mediated Ring-Opening: Stereoselective Synthesis of gamma-Lactams.
A new catalytic aldol-type addition of cyclopropanecarboximides to aldehydes via iodide-mediated ring-opening is presented. The reaction was found to be catalyzed at 0 degrees C using either a Sc(OTf)3/NaI system or ScI3. Stereoselective formation ...
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Wednesday, March 19th, 2008
One-Pot Three-Component Synthesis of alpha-Iminonitriles by IBX/TBAB-Mediated Oxidative Strecker Reaction.
The reaction of aldehydes, amines, and TMSCN in the presence of 2-iodoxybenzoic acid (IBX) and tetrabutylammonium bromide (TBAB) afforded alpha-iminonitriles in good to excellent yields under mild conditions. The presence of TBAB is essential for this ...
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Wednesday, March 19th, 2008
Palladium-Catalyzed Aromatic Esterification of Aldehydes with Organoboronic Acids and Molecular Oxygen.
A palladium-catalyzed aromatic esterification reaction of aldehydes with arylboronic acids under an air atmosphere was achieved. This reaction tolerates many functional groups and provides aryl benzoate derivatives with yields ranging from moderate to good. Dioxygen ...
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Wednesday, March 19th, 2008
Type II Isopentenyl Diphosphate Isomerase: Irreversible Inactivation by Covalent Modification of Flavin.
Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic building blocks of isoprenoid molecules. Two structurally unrelated classes of IDI are known. Type I IPP isomerase ...
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Wednesday, March 19th, 2008
Therapeutic Target Metabolism Observed Using Hyperpolarized (15)N Choline.
Choline is a precursor of cellular phospholipid metabolism that provides Magnetic Resonance (MR) and Positron Emission Tomography (PET) biomarkers for cancer detection and response assessment. Employing Dynamic Nuclear Polarization we show that the MR signal of 15N in ...
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Wednesday, March 19th, 2008
A New Catalytically Active Colloidal Platinum Nanocatalyst: The Multiarmed Nanostar Single Crytal.
Nanocatalysts that possess large amounts of atoms on sharp corners and edges and high indexed sites are known to be more catalytically active. We report here on a novel yet simple method to synthesize ...
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