Archive for the ‘researches 4’ Category
Sunday, March 16th, 2008
Pre-operative carbohydrate loading may be used in type 2 diabetes patients.
Background: Post-operative insulin resistance and hyperglycaemia are associated with an impaired outcome after surgery. Pre-operative oral carbohydrate loading (CHO) reduces post-operative insulin resistance with a reduced risk of hyperglycaemia during post-operative nutrition. Insulin-resistant diabetic patients ...
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Sunday, March 16th, 2008
Clinical pharmacology of methadone for pain.
Background: This topical review addresses methadone\'s pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time. Methods: Relevant papers were identified in PubMed and EMBASE. ...
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Sunday, March 16th, 2008
Disposition of Delta(9) tetrahydrocannabinol in CF1 mice deficient in mdr1a P-glycoprotein.
P-glycoprotein (P-gp) plays a major role in drug efflux. All the transported substrates are more or less hydrophobic and amphiphatic in nature. Being lipophilic, Delta(9) tetrahydrocannabinol (THC), the main cannabis component, could be a potential ...
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Sunday, March 16th, 2008
Smoking status moderates the association of the dopamine D4 receptor (DRD4) gene VNTR polymorphism with selective processing of smoking-related cues.
Recently, a variable number of tandem repeats (VNTR) polymorphism in the dopamine D4 receptor (DRD4) gene has been reported to be associated with greater craving and ...
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Sunday, March 16th, 2008
Cocaine craving is associated with electrophysiological brain responses to cocaine-related stimuli.
Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in ...
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Sunday, March 16th, 2008
Effects of bupropion, alone or coadministered with nicotine, on social behavior in mice.
Bupropion, administered alone or combined with nicotine, is presently used to treat nicotine dependence. Despite experimental evidence of the complex behavioral actions of this drug, there have been little data reported about its ...
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Sunday, March 16th, 2008
Protracted \'anti-addictive\' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice.
Exposure to the once highly prevalent over-the-counter (OTC) sympathomimetic phenylpropanolamine (PPA; +/--norephedrine) during pre-adolescence alters the developmental trajectory of catecholamine and amino acid neurotransmitter systems in the nucleus accumbens (NAC) that culminate in a \'pro-addictive\' phenotype ...
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Sunday, March 16th, 2008
Intellectual outcome, motor skills and BMI of children with congenital hypothyroidism: a population-based study.
Aim: To evaluate intellectual outcome, motor skills and anthropometric data of children with congenital hypothyroidism (CH). Methods: Children with permanent CH who were born in 1999 in Bavaria were eligible for this ...
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Sunday, March 16th, 2008
Neonatal testicular torsion - a lost cause?
Twenty-four neonates presented with signs of testicular ischaemia over a 13-year period. They had a mean birth weight of 3.706 kg. The right testicle was affected in 13, the left in 9 and there was bilateral torsion in 2 ...
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Sunday, March 16th, 2008
Hypoechoic thyroid nodules on ultrasound 4 years after prenatal exposure to radioiodine: resolution with thyroxine therapy.
We describe an infant inadvertently exposed to radioiodine at 17 weeks gestation. His mother had received 400 MBq of (131)I for hyperthyroidism (total T4 178 nmol/L, thyroid stimulating hormone (TSH) ...
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Sunday, March 16th, 2008
Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis.
de Lavallade H, Punnialingam S, Milojkovic D, Bua M, Khorashad JS, Gabriel IH, Chaidos A, Olavarria E, Goldman JM, Apperley JF, Marin D.
Department of Haematology, Hammersmith Hospitals ...
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Sunday, March 16th, 2008
Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation test.
Background beta-Lactam (BL) antibiotics can induce non-immediate skin reactions, frequently manifested as exanthema or urticaria. The time between drug intake and the reaction appearance is generally 24-48 h. Because the mechanisms involved are ...
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Sunday, March 16th, 2008
Comparison of two basophil activation markers CD63 and CD203c in the diagnosis of amoxicillin allergy.
Background To confirm allergy to beta-lactam (BL), a basophil activation test in flow cytometry based on CD63 up-regulation was described. CD203c is a more recent basophil activation marker and up to ...
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Sunday, March 16th, 2008
A new method of measuring lens refractive index.
A new clinical method for determining the refractive index of a lens is described. By measuring lens power in air and then immersing the lens in a liquid of known refractive index (n), it is possible to calculate ...
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Sunday, March 16th, 2008
Growth of the lens: in vitro observations.
Understanding the normal functioning of the human lens and its role in the development of disorders of vision, such as presbyopia and cataract, requires a thorough knowledge of how the lens grows and how its properties change with age. ...
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Sunday, March 16th, 2008
Eubacterium plautii infection in a kidney transplant recipient: a noteworthy case of pleural effusion and fever.
We report a noteworthy case of Eubacterium plautii infection after kidney transplantation. Our 33-yr-old transplant recipient received standard care; his post-transplant course was uneventful. However, on day 44 he underwent ...
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Sunday, March 16th, 2008
\'My pupil has gone black!\' Subluxation of a total cataractous lens.
A patient with a history of longstanding opaque cataract and a white pupil reported a return to a black pupil, which was the result of lens subluxation. The case was complicated by optic nerve coloboma ...
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Sunday, March 16th, 2008
hhLIM is a novel F-actin binding protein involved in actin cytoskeleton remodeling.
Human heart LIM protein (hhLIM) is a newly cloned protein. In vitro analyses showed that green fluorescent protein (GFP)-tagged hhLIM protein accumulated in the cytoplasm of C2C12 cells and colocalized with F-actin, indicating that ...
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Sunday, March 16th, 2008
Functional domains of the human epididymal protease inhibitor, eppin.
Eppin has two potential protease inhibitory domains: a whey acid protein or four disulfide core domain and a Kunitz domain. The protein is also reported to have antibacterial activity against Gram-negative bacteria. Eppin and its whey acid ...
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Sunday, March 16th, 2008
The amyloplast proteome of potato tuber.
Potato (Solanum tuberosum) is the fourth largest crop worldwide in yield, and cv. Kuras is the major starch potato of northern Europe. Storage starch is packed densely in tuber amyloplasts, which become starch granules. Amyloplasts of soil-grown mini-tubers and agar-grown ...
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Sunday, March 16th, 2008
The complex of the insect LDL receptor homolog, lipophorin receptor, LpR, and its lipoprotein ligand does not dissociate under endosomal conditions.
The insect low-density lipoprotein (LDL) receptor (LDLR) homolog, lipophorin receptor (LpR), mediates endocytic uptake of the single insect lipoprotein, high-density lipophorin (HDLp), which is structurally ...
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Sunday, March 16th, 2008
Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana.
Exposure of Arabidopsis thaliana plants to high levels of light revealed specific phosphorylation of a 40 kDa protein in photosynthetic thylakoid membranes. The protein was identified by MS as extracellular calcium-sensing receptor ...
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Sunday, March 16th, 2008
Cholesterol interaction with the related steroidogenic acute regulatory lipid-transfer (START) domains of StAR (STARD1) and MLN64 (STARD3).
The steroidogenic acute regulatory (StAR)-related lipid transfer (START) domains are found in a wide range of proteins involved in intracellular trafficking of cholesterol and other lipids. Among the START ...
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Sunday, March 16th, 2008
CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol - potential role(s) for estrogen signaling.
CYP7B1, a cytochrome P450 enzyme, metabolizes several steroids involved in hormonal signaling including 5alpha-androstane-3beta,17beta-diol (3beta-Adiol), an estrogen receptor agonist, and dehydroepiandrosterone, a precursor for sex hormones. Previous studies have suggested that CYP7B1-dependent metabolism involving ...
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Sunday, March 16th, 2008
Interaction and functional association of protein disulfide isomerase with alpha(V)beta(3) integrin on endothelial cells.
Adhesive properties of endothelial cells are influenced by the thioldisulfide balance. However, the molecular mechanism of this effect is unclear, although recent observations indicate that integrin receptors may be direct targets for ...
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