Archive for the ‘researches 4’ Category
Sunday, March 16th, 2008
The role of GABAergic transmission in the dentate gyrus on acquisition, consolidation and retrieval of an inhibitory avoidance learning and memory task in the rat.
The hippocampal GABAergic interneurons are responsible for controlling the input of large principal cell populations, and they thereby determine the oscillatory ...
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Sunday, March 16th, 2008
Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates.
The expression of the Siglec family of molecules by hematopoietic cells from uninfected and SIV infected disease susceptible rhesus macaques (RM) and SIV infected disease resistant sooty mangabeys (SM) ...
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Sunday, March 16th, 2008
Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors.
UbcH10 is one of the key regulators of cell cycle progression through the mitotic spindle assembly checkpoint pathway. Recently, aberrantly high UbcH10 expression has been demonstrated in a variety of malignancies. However, its role in astrocytic carcinogenesis is ...
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Sunday, March 16th, 2008
Two Cell Lineages, myf5 and myf5-Independent, Participate in Mouse Skeletal Myogenesis.
In skeletal muscle development, the myogenic regulatory factors myf5 and myoD play redundant roles in the specification and maintenance of myoblasts, whereas myf6 has a downstream role in differentiating myocytes and myofibers. It is not ...
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Sunday, March 16th, 2008
A Mutual Inhibition between APC/C and Its Substrate Mes1 Required for Meiotic Progression in Fission Yeast.
The anaphase-promoting complex/cyclosome (APC/C) is a cell-cycle-regulated essential E3 ubiquitin ligase; however, very little is known about its meiotic regulation. Here we show that fission yeast Mes1 is a substrate ...
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Sunday, March 16th, 2008
Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus.
Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify ...
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Sunday, March 16th, 2008
Genome-wide identification of smad/foxh1 targets reveals a role for foxh1 in retinoic Acid regulation and forebrain development.
Foxh1, a Smad DNA-binding partner, mediates TGFbeta-dependent gene expression during early development. Few Foxh1 targets are known. Here, we describe a genome-wide approach that we developed that couples systematic ...
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Sunday, March 16th, 2008
PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy.
Autophagy, an intrinsically nonselective process, can also target selective cargo for degradation. The mechanism of selective peroxisome turnover by autophagy-related processes (pexophagy), termed micropexophagy and macropexophagy, is unknown. We show how a Pichia pastoris protein, PpAtg30, mediates peroxisome ...
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Sunday, March 16th, 2008
Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye.
In multicellular organisms, apoptotic cells induce compensatory proliferation of neighboring cells to maintain tissue homeostasis. In the Drosophila wing imaginal disc, dying cells trigger compensatory proliferation through secretion of the mitogens ...
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Sunday, March 16th, 2008
Crag regulates epithelial architecture and polarized deposition of basement membrane proteins in Drosophila.
The polarized architecture of epithelia relies on an interplay between the cytoskeleton, the trafficking machinery, and cell-cell and cell-matrix adhesion. Specifically, contact with the basement membrane (BM), an extracellular matrix underlying the basal ...
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Sunday, March 16th, 2008
sSgo1, a Major Splice Variant of Sgo1, Functions in Centriole Cohesion Where It Is Regulated by Plk1.
Shugoshin 1 (Sgo1) functions as a protector of centromeric cohesion of sister chromatids in higher eukaryotes. Here, we provide evidence for a previously unrecognized role for Sgo1 in centriole ...
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Sunday, March 16th, 2008
Nudel Binds Cdc42GAP to Modulate Cdc42 Activity at the Leading Edge of Migrating Cells.
Cdc42GAP promotes inactivation of Cdc42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration. How Cdc42GAP is regulated to ensure proper levels ...
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Sunday, March 16th, 2008
Intron Delays and Transcriptional Timing during Development.
The time taken to transcribe most metazoan genes is significant because of the substantial length of introns. Developmentally regulated gene networks, where timing and dynamic patterns of expression are critical, may be particularly sensitive to intron delays. We revisit ...
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Sunday, March 16th, 2008
Wnt/beta-Catenin Signaling: Turning the Switch.
The regulation of many targets of the Wnt/beta-catenin signaling pathway is thought to occur through a transcriptional switch that is achieved by beta-catenin binding to TCF transcription factors. Recent work indicates that beta-catenin\'s intrinsic affinity for TCF is not sufficient for ...
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Sunday, March 16th, 2008
Plant Cell Polarity: Sterols Enter into Action after Cytokinesis.
In yeast and animal cells, the sterol composition of membranes is a key factor that controls the polarity of membrane proteins by regulating their intracellular trafficking or lateral diffusion. A recent study in Nature Cell Biology demonstrates ...
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Sunday, March 16th, 2008
sSgo1, a Guardian of Centriole Cohesion.
Sgo1 plays a key role in protecting sister chromatid cohesion during mitosis. In this issue of Developmental Cell, Wang et al. describe a shorter splice variant of Sgo1 (sSgo1) that functions specifically in centriole cohesion. sSgo1 may be the \"glue\" ...
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Sunday, March 16th, 2008
Signaling to nuclear transport.
In a recent issue of Molecular Cell, Yoon et al. provide evidence for the control of nucleocytoplasmic transport by protein kinase signaling pathways through phosphorylation of RanBP3, an accessory factor in the Ran GTPase system. This mechanism may coordinate nucleocytoplasmic transport with ...
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Sunday, March 16th, 2008
Yorkie and scalloped: partners in growth activation.
The Hippo (Hpo) signaling pathway limits organ growth in organisms from Drosophila to mammals by suppressing the activity of the transcriptional coactivator Yorkie (Yki)/YAP. The TEAD/TEF factor Scalloped (Sd) has been identified as the first known transcription factor to ...
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Sunday, March 16th, 2008
Hungry for blood vessels: linking metabolism and angiogenesis.
A new study by Arany et al. demonstrates that the metabolic master regulator peroxisome proliferator-activated receptor (PPARgamma) coactivator-1alpha (PGC-1alpha) can promote angiogenesis. These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities ...
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Sunday, March 16th, 2008
Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling.
OBJECTIVES: To investigate the accuracy of predictive tests for pre-eclampsia and the effectiveness of preventative interventions for pre-eclampsia. Also to assess the cost-effectiveness of strategies (test-intervention combinations) to predict ...
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Sunday, March 16th, 2008
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
The objective of the present study was to evaluate the time course of changes in peripheral nerve insulin receptor (IR) signaling and compare observed findings with behavioral responses to noxious mechanical ...
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Sunday, March 16th, 2008
A multi-centre retrospective cohort study comparing the efficacy, safety and cost-effectiveness of hysterectomy and uterine artery embolisation for the treatment of symptomatic uterine fibroids. The HOPEFUL study.
OBJECTIVES: To examine and compare the medium-term results of hysterectomy and uterine artery embolisation (UAE) as a treatment for ...
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Sunday, March 16th, 2008
[Splenic metastasis in ovary serous adenocarcinoma]
Splenic metastasis is rare, and is usually associated with disseminated malignancy. The primary tumours more frequently related with splenic metastasis are lung, breast, gynaecologic, specially ovary tumours, colon, rectum and melanoma. Isolated secondary splenic disease is rare, but it is ...
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Sunday, March 16th, 2008
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Sunday, March 16th, 2008
[XYY male with right aortic arch and ligamentum arteriosum: a fortuitus association?]
INTRODUCTION: The XYY male has characteristicaly tall stature, behavior problems and speech delay. There may may be an association with nephro-urologic malformations but cardiovascular anomalies are usually not present. CASE REPORT: It is reported ...
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