Archive for the ‘for377cat’ Category
Friday, June 27th, 2008
Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1.
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion injury in vivo, and this has been attributed to its ability to ...
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Friday, June 27th, 2008
Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels.
Tanshinone IIA, one of the main active components from Chinese herb Danshen, is widely used to treat cardiovascular diseases including arrhythmia in Asian countries especially in China. However, the mechanisms underlying its anti-arrythmia effects ...
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Friday, June 27th, 2008
Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse.
We hypothesized that lack of a functional serotonin transporter (SERT) would increase basal blood pressure and enhance the development of deoxycorticosterone acetate (DOCA)-salt hypertension compared to wild type (WT) controls. Mean arterial ...
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Friday, June 27th, 2008
Peripheral nerve injury alters spinal nicotinic acetylcholine receptor pharmacology.
Nicotinic acetylcholine receptors are widely expressed in the rat spinal cord and modulate innocuous and nociceptive transmission. The present studies were designed to investigate the plasticity of spinal nicotinic acetylcholine receptors modulating mechanosensitive information following spinal nerve ...
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Friday, June 27th, 2008
Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition.
Agmatine, a decarboxylation product of arginine, is thought to be an important neuromodulator in the mammalian brain. It is proposed to exert neuroprotective, anxiolytic and antidepressant effects. The receptor-binding profile of agmatine is complex and includes ...
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Friday, June 27th, 2008
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
Treatment of obesity is still a large unmet medical need. Neuropeptide Y is the most potent orexigenic peptide in the animal kingdom. Its five cloned G-protein couple receptors are all ...
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Friday, June 27th, 2008
B-type natriuretic peptides for the diagnosis of congestive heart failure in dyspneic oldest-old patients.
OBJECTIVES: To evaluate the accuracy of B-type natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) for the diagnosis of congestive heart failure (CHF) in dyspneic patients aged >/=85 years admitted to ...
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Friday, June 27th, 2008
Variation of serum creatinine, cystatin C, and creatinine clearance tests in persons with normal renal function.
BACKGROUND: To determine the potential sensitivity of several renal function tests for detecting early changes in renal function, we compared the within-individual (W-I) variation over 5 months of serum creatinine, ...
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Friday, June 27th, 2008
Cytotoxic and genotoxic effects of tambjamine D, an alkaloid isolated from the nudibranch Tambja eliora, on Chinese hamster lung fibroblasts.
Marine organisms have been shown to be potential sources of bioactive compounds with pharmaceutical applications. Previous chemical investigation of the nudibranch Tambja eliora led to the ...
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Friday, June 27th, 2008
Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer\'s disease.
Alzheimer\'s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. It is the most common type of dementia in the ageing population due to a severe loss of cholinergic neurons in ...
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Friday, June 27th, 2008
Fast (100-175 ms) components elicited bilaterally by language production as measured by three-wavelength optical imaging.
Optical imaging has been gradually utilized to investigate language functions in the brain. The majority of hemodynamic response (slow signal) measurements have been applied to receptive and productive language processing, while ...
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Friday, June 27th, 2008
When a high-intensity \"distractor\" is better then a low-intensity one: Modeling the effect of an auditory or tactile nontarget stimulus on visual saccadic reaction time.
In a focused attention task saccadic reaction time (SRT) to a visual target stimulus (LED) was measured with an auditory (white ...
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Friday, June 27th, 2008
Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhage.
Previous studies show that intravascular injection of human bone marrow stromal cells (hBMSCs) significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). In the present study, we tested ...
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Friday, June 27th, 2008
Influences of multiple tooth-losses during developmental periods on age-dependent emergence of oscillatory neural activities in the oral somatosensory cortex.
Tooth and tooth-related organs play important roles in not only mastication, but also sensory perception in the oral region. In general, sensory neural inputs during the developmental ...
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Friday, June 27th, 2008
Distinct actions of strontium on mineral formation in matrix vesicles.
Matrix vesicles (MVs) are involved in the initial step of mineralization in skeletal tissues and provide an easily model to analyze the hydroxyapatite (HA) formation. Sr stimulates bone formation and its effect was tested on MVs. ...
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Friday, June 27th, 2008
The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly exchanges between secretory granules and cytosol in PC12 cells.
Rab proteins are GTPases that transit between GTP- and GDP-bound states. In the GTP-bound form they can recruit specific effector to membrane domains. It is possible that the ...
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Friday, June 27th, 2008
Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion.
Flavivirus pre-membrane (prM) protein is important for proper folding and secretion of envelope (E) protein. However, other non-structural functions of prM protein in the context of virus life-cycle are poorly known. ...
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Friday, June 27th, 2008
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells.
SIRT1, which belongs to the family of type III histone deacetylase, is implicated in diverse cellular processes. We have determined the expression levels of SIRT1 in human prostate cancer cell ...
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Friday, June 27th, 2008
Extracellular calcium- and magnesium-mediated regulation of passive calcium transport across Caco-2 monolayers.
The calcium-sensing receptor (CaR) is expressed on intestinal epithelial serosal membrane and in Caco-2 cells. In renal epithelium, CaR expressed on the basolateral membrane acts to limit excess tubular Ca(2+) reabsorption. Therefore, here we ...
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Friday, June 27th, 2008
Convenient preparation and characterization of a monoclonal antibody for the N-linked sugar chain of a glycoprotein using a microbial endoglycosidase.
We attempted to obtain the monoclonal antibody specific for the N-linked complex-type sialo-oligosaccharide in glycoproteins. We first synthesized a chimeric immunoantigen having an N-linked complex-type of ...
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Friday, June 27th, 2008
\'Relating\' to voices: Exploring the relevance of this concept to people who hear voices.
ObjectivesConceptualizing interactions between voice hearers and their voices as a \'relationship\' has recently become an area of psychological inquiry. To date the literature exploring the details of a hearer-voice relationship has arguably ...
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Friday, June 27th, 2008
The Penrose hypothesis in 2004: Patient and prisoner numbers are positively correlated in low-and-middle income counties but are unrelated in high-income countries.
ObjectiveTo examine the relationship between the numbers of psychiatric hospital beds and prisoners using recent statistics.DesignAn analysis of published data from 158 countries.MethodsMultiple linear ...
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Friday, June 27th, 2008
Evolving concepts of type 2 diabetes management with oral medications: new approaches to an old disease.
BACKGROUND: Type 2 diabetes is often accompanied by co-morbid conditions such as hypertension and dyslipidemia, which, coupled with persistent hyperglycemia, result in significant macrovascular and microvascular complications. Type 2 diabetes ...
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Friday, June 27th, 2008
Responding mindfully to unpleasant thoughts and images: Reliability and validity of the Southampton mindfulness questionnaire (SMQ).
ObjectiveTo assess the reliability and validity of the Southampton mindfulness questionnaire (SMQ), a 16-item measure of mindful awareness of distressing thoughts and images.MethodsA total of 256 people participated, comprising a ...
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Friday, June 27th, 2008
An effect size index for comparing two independent alpha coefficients.
Since Cronbach proposed the alpha coefficient in 1951, researchers have contributed to the derivation of its sampling distribution and the testing of related statistical hypotheses. Yet, there has been no research on effect size index relevant ...
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