Archive for the ‘for377cat’ Category
Friday, June 27th, 2008
Increase of Dkk-3 blood plasma levels in the elderly.
Gene expression of the secreted glycoprotein Dkk-3 is upregulated during cellular senescence in prostate basal epithelial cells and altered in age-related disorders of the human prostate. In order to quantify the influence of such age- and disease-related ...
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Friday, June 27th, 2008
Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells.
During the lifetime of an adult organism, stem cells face extrinsic and intrinsic aging. Mesenchymal stem cells (MSC) can be expanded in culture, and ...
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Friday, June 27th, 2008
Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening.
OBJECTIVE: To investigate the stem bark of Sideroxylon inerme L. and its compounds for tyrosinase-inhibition activity and to evaluate the mechanism involved of the most potent compounds ...
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Friday, June 27th, 2008
Three-dimensional imaging of the intact mouse cochlea by fluorescent laser scanning confocal microscopy.
The complex anatomy of the mammalian cochlea is most readily understood by representation in three-dimensions. However, the cochlea is often sectioned to minimize the effects of its anatomic complexity and optical properties on ...
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Friday, June 27th, 2008
Age-related auditory pathology in the CBA/J mouse.
Commercially obtained aged male CBA/J mice presented a complex pattern of hearing loss and morphological changes. A significant threshold shift in auditory brainstem responses (ABR) occurred at 3 months of age at 4kHz without apparent loss of hair cells, ...
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Friday, June 27th, 2008
Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system.
Research in animal models has demonstrated that electrical stimulation from a cochlear implant (CI) may help prevent degeneration of the cochlear spiral ganglion (SG) neurons after deafness. In cats deafened early in life, ...
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Friday, June 27th, 2008
Localized cell and drug delivery for auditory prostheses.
Localized cell and drug delivery to the cochlea and central auditory pathway can improve the safety and performance of implanted auditory prostheses (APs). While generally successful, these devices have a number of limitations and adverse effects including limited ...
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Friday, June 27th, 2008
Evaluation of dynamic image analysis for characterizing pharmaceutical excipient particles.
The capability of the newly developed dynamic image analysis instrument QicPic equipped with the high-speed dry-powder-dispersing device was investigated systematically using various MCC particles. Instrument cross-validation was conducted by comparing the particle size distribution of spherical ...
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Friday, June 27th, 2008
Microwave generated solid dispersions containing Ibuprofen.
The purpose of this study was to apply the attractive technique of the microwaves irradiation (MW) for the preparation of solvent-free solid dispersions (SD). In particular, the microwave technology has been considered in order to prepare an enhanced release dosage ...
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Friday, June 27th, 2008
Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir.
The objective of this study was to synthesize and evaluate novel enzymatically stable dipeptide prodrugs for improved absorption of acyclovir. l-Valine-l-valine-acyclovir (LLACV), l-valine-d-valine-acyclovir (LDACV), d-valine-l-valine-acyclovir (DLACV) and d-valine-d-valine-acyclovir (DDACV) were successfully synthesized. The uptake ...
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Friday, June 27th, 2008
Isolated swine heart ventricle perfusion model for implant assisted-magnetic drug targeting.
An isolated swine heart ventricle perfusion model was developed and used under physiologically relevant conditions to study implant assisted-magnetic drug targeting (IA-MDT). A stent coil was fabricated from a ferromagnetic SS 430 wire and used ...
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Friday, June 27th, 2008
Characterization of a novel portal protein from deep-sea thermophilic bacteriophage GVE2.
Portal proteins, located asymmetrically at one of the twelve vertices of the capsid, play very important roles in viral DNA packaging. Compared with the well-studied portal proteins of bacteriophages infecting mesophilic bacteria, portal proteins of ...
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Friday, June 27th, 2008
Genome duplication and gene-family evolution: The case of three OXPHOS gene families.
DNA duplication is one of the main forces acting on the evolution of organisms because it creates the raw genetic material that natural selection can subsequently modify. Duplicated regions are mainly due to \"errors\" ...
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Friday, June 27th, 2008
The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat.
Overlapped in the tuberal hypothalamic area (THA), melanin-concentrating hormone (MCH) and hypocretin (Hcrt) neurons contribute to the integrated regulation of food intake, energy regulation and sleep. Recently, physiological role ...
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Friday, June 27th, 2008
PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex.
Protein arginine methyltransferase 3 (PRMT3) comprises a region not required for catalytic activity in its amino-terminus and the core domain catalyzing protein arginine methylation. PRMT3 has been shown to interact with the ...
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Friday, June 27th, 2008
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer\'s disease.
Single nucleotide polymorphisms (SNPs) in diabetes related peroxisome proliferator-activated receptor gamma (PPARG) gene were investigated with a case-control approach. To examine the genetic association of this gene with Alzheimer\'s disease (AD) risk, we ...
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Friday, June 27th, 2008
Antimicrobial properties of lactoferrin.
Milk is a vital nutritional source for the offspring of all mammals, including humans. In addition to its nutritional value, it is a rich source of proteins including lactoferrin. Lactoferrin is a truly multifunctional protein that has been studied extensively over the ...
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Friday, June 27th, 2008
Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of Herpes simplex virus-1.
Although both lactoferrin (Lf), a component of the innate immune system of living organisms, and its N-terminal pepsin cleavage product lactoferricin (Lfcin) have anti-herpes activity, the precise mechanisms by which Lf and Lfcin bring ...
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Friday, June 27th, 2008
Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides.
The innate immunity factor lactoferrin harbours two antimicrobial moieties, lactoferricin and lactoferrampin, situated in close proximity in the N1 domain of the molecule. Most likely they cooperate ...
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Friday, June 27th, 2008
In silico analysis of structural and functional consequences in p16INK4A by deleterious nsSNPs associated CDKN2A gene in malignant melanoma.
In this study, we identified the most deleterious nsSNP in CDKN2A gene through structural and functional properties of its protein (p16INK4A) and investigated its binding affinity with ...
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Friday, June 27th, 2008
A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica.
Secreted cysteine proteases are relevant actors in parasite biology, taking part in critical host colonization roles such as traversing tissue barriers, immune evasion and nutrient digestion. In the trematode Fasciola hepatica, the initial step ...
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Friday, June 27th, 2008
Isolation and characterization of \"Reprotoxin\", a novel protein complex from Daboia russelii snake venom.
In snake venoms, non-covalent protein-protein interaction leads to protein complexes with synergistic and, at times, distinct pharmacological activities. Here we describe a new protein complex containing phospholipaseA(2) (PLA(2)), protease, and a trypsin ...
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Friday, June 27th, 2008
Molecular cloning, expression and characterization of a novel apoplastic invertase inhibitor from tomato (Solanum lycopersicum) and its use to purify a vacuolar invertase.
Protein inhibitors are molecules secreted by many plants. In a functional genomics approach, an invertase inhibitor (SolyCIF) of Solanum lycopersicum was identified at ...
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Friday, June 27th, 2008
d-galactose administration induces memory loss and energy metabolism disturbance in mice: Protective effects of catalpol.
The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh rehmannia roots, on the behavior and brain energy metabolism in senescent mice induced by d-galactose were assessed. Except control ...
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Friday, June 27th, 2008
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
One of the pathological hallmarks of Alzheimer\'s disease is the progressive accumulation of beta-amyloid (Abeta in the form of senile plaques, and Abeta insult to neuronal cells has been identified ...
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