Archive for the ‘for26cat’ Category
Saturday, June 28th, 2008
Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids.
Supercritical or near-critical fluid processes for generating microparticles have enjoyed considerable attention in the past decade or so, with good success for substances soluble in supercritical fluids or organic solvents. In ...
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Saturday, June 28th, 2008
A Novel Nanocapsule Delivery System to Overcome Intestinal Degradation and Drug Transport Limited Absorption of P-glycoprotein Substrate Drugs.
PURPOSE: To design a double-coated nanoparticulate delivery system of tacrolimus capable of overcoming the P-glycoprotein pump and CYP3A barriers without affecting their physiological activities. MATERIALS AND METHODS: Tacrolimus ...
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Saturday, June 28th, 2008
Production of Ultrafine Sumatriptan Succinate Particles for Pulmonary Delivery.
PURPOSE: Drug particle physical properties are critical for the efficiency of a drug delivered to the lung. The purpose of this study was to produce ultrafine sumatriptan succinate particles for inhalation. METHODS: Sumatriptan succinate particles were produced ...
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Saturday, June 28th, 2008
Cyclooxygenase Inhibitors Down Regulate P-glycoprotein in Human Colorectal Caco-2 Cell Line.
PURPOSE: Elevated expression of the ABC transporters P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) seems to correlate with multidrug resistance of cancer cells. In this study we investigated the effect of COX inhibitors in ...
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Saturday, June 28th, 2008
Decreased Lithium Disposition to Cerebrospinal Fluid in Rats with Glycerol-induced Acute Renal Failure.
PURPOSE: The lithium disposition to cerebrospinal fluid (CSF) was evaluated in rats with acute renal failure (ARF) to examine whether electrolyte homeostasis of the CSF is perturbed by kidney dysfunction. In addition, the ...
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Saturday, June 28th, 2008
Tumor Endothelial Cell Targeted Cyclic RGD-modified Heparin Derivative: Inhibition of Angiogenesis and Tumor Growth.
PURPOSE: We prepared tumor endothelium targeted cRGD-modified heparin derivative (cRGD-HL) by coupling heparin-lithocholic acid (HL) with cRGDyK, and evaluated inhibition effects of cRGD-HL on angiogenesis and tumor growth. METHODS: To evaluate antiangiogenic ...
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Saturday, June 28th, 2008
Colorimetric Polymer Films for Predicting Lipid Interactions and Percutaneous Adsorption of Pharmaceutical Formulations.
PURPOSE: To develop and demonstrate a rapid and simple colorimetric film assay for evaluating lipid interactions of pharmaceutical compounds and gel formulations. METHODS: The colorimetric assay comprises glass-supported films of phospholipids and polydiacetylene, ...
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Saturday, June 28th, 2008
Investigation of Electrostatic Behavior of a Lactose Carrier for Dry Powder Inhalers.
PURPOSE: This study aims to elucidate the electrostatic behavior of a model lactose carrier used in dry powder inhaler formulations by examining the effects of ambient relative humidity (RH), aerosolization air flow rate, repeated ...
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Saturday, June 28th, 2008
Global Gene Expression Profiling in Cultured Cells Is Strongly Influenced by Treatment with siRNA-Cationic Liposome Complexes.
PURPOSE: The purpose of this study is to determine if the treatment with siRNA-lipoplexes significantly influences on global gene expression in the treated cells. METHODS: We investigated global gene expression ...
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Saturday, June 28th, 2008
Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin.
Arginine vasopressin (AVP) has been shown to directly induce neonatal rat cardiac fibroblasts (CFs) proliferation, a major component involved in cardiac hypertrophy. Herein, ...
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Saturday, June 28th, 2008
Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats.
Cardiac fibrosis represented as perivascular/interstial fibrosis occurs in patients with hypertension. Oxidative stress has been demonstrated to contribute to such structural remodeling. The underlying mechanisms, however, remain to be elucidated. Herein, we tested ...
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Saturday, June 28th, 2008
Role of MyD88 in TLR agonist-induced functional alterations of human adipose tissue-derived mesenchymal stem cells.
Toll-like receptors (TLRs) sense microorganism components and are critical host mediators of inflammation during infection. Recently, TLRs have been reported to be involved in cell proliferation and differentiation. We previously reported ...
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Saturday, June 28th, 2008
Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload.
Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), ...
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Saturday, June 28th, 2008
Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes.
Many patients with bone marrow failure syndromes need frequent transfusions of red blood cells, and most of them eventually suffer from organ dysfunction induced by excessively accumulated ...
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Saturday, June 28th, 2008
Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression.
Friedreich\'s ataxia is an autosomal recessive neurodegenerative disease that is due to the loss of function of the frataxin protein. The molecular basis of this disease is still a matter of debate and treatments have ...
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Saturday, June 28th, 2008
Comparative Evaluation of the Cerebral and Cerebellar White Matter Development in Pediatric Age Group using Quantitative Diffusion Tensor Imaging.
Age-dependent changes in the normal cerebral white matter have been reported; however, there is no study on normal cerebellar white matter maturation in developing brain using diffusion ...
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Saturday, June 28th, 2008
Lack of Axial Rotation in Mobile-bearing Knee Designs.
It has often been assumed rotational kinematics are improved with mobile-bearing TKA designs as the terms mobile-bearing and rotating platform imply. We tested this assumption by assessing the in vivo axial rotation magnitudes and patterns of 527 knees ...
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Saturday, June 28th, 2008
Gastric Bypass Surgery in Rats Produces Weight Loss Modeling after Human Gastric Bypass.
BACKGROUND: The study of the mechanisms of weight loss after bariatric surgery requires an animal model that mimics the human procedure and subsequent weight loss. A rat model eliminates the cognitive efforts associated ...
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Saturday, June 28th, 2008
Incidence of Marginal Ulcer 1 Month and 1 to 2 Years After Gastric Bypass: A Prospective Consecutive Endoscopic Evaluation of 442 Patients with Morbid Obesity.
BACKGROUND: Marginal ulcer (MU) is an occasional complication after gastric bypass. We studied the incidence of this complication by a prospective ...
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Saturday, June 28th, 2008
An Improved Intragastric Balloon Procedure Using a New Balloon: Preliminary Analysis of Safety and Efficiency.
BACKGROUND: The authors developed a new intragastric balloon procedure with the objective of making it safer, faster, and less expensive than the established ones. The proposed procedure uses a new gastric ...
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Saturday, June 28th, 2008
Retrograde Endoscopic Cystgastrostomy for Pancreatic Pseudocyst Drainage after a Prior Roux-en-Y Gastric Bypass.
A 47-year-old woman with a history of Roux-en-Y gastric bypass developed a pancreatic pseudocyst after an episode of acute necrotizing pancreatitis. She presented with intractable abdominal pain and weight loss. Computed tomography scan ...
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Saturday, June 28th, 2008
Additional Effect of Visceral Fat Resection in an Obese Rat Model of Gastric Banding.
BACKGROUND: There is accumulating agreement that bariatric surgery is currently the most efficacious and enduring treatment for clinically severe obesity, and as a result, the number of bariatric surgeries performed worldwide has ...
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Saturday, June 28th, 2008
What if the Federal Government Negotiated Pharmaceutical Prices for Seniors? An Estimate of National Savings.
BACKGROUND: The government is prohibited from directly negotiating drug prices for Medicare Part D, resulting in substantial policy debate. However, the government has an established mechanism for setting prices with pharmaceutical ...
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Saturday, June 28th, 2008
Self-Reported Peripheral Arterial Disease Predicts Future Vascular Events in a Community-Based Cohort.
BACKGROUND: Lower extremity peripheral arterial disease (PAD) is highly prevalent and strongly associated with cardiovascular morbidity and mortality. The ankle-brachial index used to screen for PAD is not routinely performed in primary care settings. ...
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Saturday, June 28th, 2008
Treatment Outcomes in Anaplastic Thyroid Carcinoma: Survival Improvement in Young Patients With Localized Disease Treated by Combination of Surgery and Radiotherapy.
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a notoriously aggressive malignancy associated with a highly lethal clinical course despite therapeutic intervention. Our present study attempts to ...
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