Wnt/beta-Catenin Signaling: Turning the Switch.
March 16th, 2008 | by admin |Wnt/beta-Catenin Signaling: Turning the Switch.
The regulation of many targets of the Wnt/beta-catenin signaling pathway is thought to occur through a transcriptional switch that is achieved by beta-catenin binding to TCF transcription factors. Recent work indicates that beta-catenin\’s intrinsic affinity for TCF is not sufficient for the switch to occur.
Cadigan KM.
Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.