The effects of antidepressants in Parkinson’s disease: a meta-analysis.
May 1st, 2008 | by admin |The effects of antidepressants in Parkinson\’s disease: a meta-analysis.
This study explored the therapeutic effect of antidepressants in Parkinson\’s disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p < .01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p < .01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07), adverse events were negligible with SSRIs (odds ratio = 1.83) and selegeline (odds ratio = 1.63). Antidepressants can be beneficial for patients with PD. However, the choice of antidepressants needs to take depressive symptomatologies into account while monitoring side effects.
Frisina PG, Tenenbaum HR, Borod JC, Foldi NS.
Leir Parkinson\’s Disease Program, The Jewish Home and Hospital Lifecare System, New York, New York, USA.