[The effect of entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and
June 27th, 2008 | by admin |[The effect of entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion.]
OBJECTIVE: To investigate the effect of Entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion. METHODS: Serum aminotransferase (ALT), HBV DNA and HBeAg were monitored before the after entecavir treatment. At the same time point, HBV-specific T cell proliferation was determined by [3H] T-dR incorporation assay, while HBV-specific IFN-a secretion was measured by ELISA. RESULTS: The level of HBV DNA and ALT was significantly decreased after entecavir treatment. Same is the titer of HBeAg. In addition, HBeAg sero-conversion was observed in some of them, in whom the HBV-specific T cell proliferation and IFN-a production were significantly increased. CONCLUSION: Entecavir treatment resulted in increased HBV-specific immunity along with the inhibition of HBV replication. [Key words] Entecavir; Hepatitis B virus; Immunity, cellular.
Li JX.
Shenzhen Luohu Hospital, Shenzhen, 518000, China.