The Endosteum Region Keeps Human Leukemic Stem Cells Alive.
March 29th, 2008 | by admin |The Endosteum Region Keeps Human Leukemic Stem Cells Alive.
Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34(+)CD38(-) stem cells, which are retained in the endosteum region.
Lapidot T, Goichberg P, Lapid K, Avigdor A, Kollet O.
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel; The Helen and Martin Kimmel Center for Stem Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.