Tardive Seizure and Antibiotics: Case Reports and Review of the Literature.
June 28th, 2008 | by admin |Tardive Seizure and Antibiotics: Case Reports and Review of the Literature.
ABSTRACT: Tardive seizure is a serious adverse reaction of electroconvulsive therapy (ECT). However, it was rarely reported in ECT sessions for psychiatric patients who needed concurrent antibiotic treatments. We present 2 cases of patients with schizophrenia who manifested a catatonic syndrome and were indicated for ECT, along with antibiotic therapies for infectious diseases with piperacillin and cefotiam, respectively. The beta-lactam antibiotics are reported to induce convulsions caused by the suppression of inhibitory GABAergic functions. In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics. Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.
Saito T, Nakamura M, Watari M, Isse K.
From the Department of Psychiatry, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan.