Synthesis of 3′-deoxy-3′-C-methyl nucleoside derivatives.
June 28th, 2008 | by admin |Synthesis of 3\’-deoxy-3\’-C-methyl nucleoside derivatives.
2\’,3\’-Dideoxy-3\’-C-methyl nucleosides bearing the five naturally occurring nucleic acid bases were synthesized. Additionally, the 3\’-deoxy-3\’-C-methyl nucleoside analogues bearing 5-aminoimidazole-4-carboxamide as well as 1,2,4-triazole-3-carboxamide moieties were prepared. The synthesis of the corresponding 2\’,3\’-dideoxy-3\’-C-methyl triazole derivative was also accomplished. The dideoxynucleoside derivatives were prepared by radical deoxygenation from their 3\’-deoxy-3\’-C-methyl parent ribonucleosides. When evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
Aljarah M, Couturier S, Mathé C, Périgaud C.
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM 1-UM 2, Université Montpellier 2, Case Courrier 1705, Place E. Bataillon, 34095 Montpellier cedex 05, France.