Synthesis and Antimicrobial Study of Novel 1-Aryl-2-oxo-indano[3,2-d]pyrido/pyrimido[1,2-b]pyrimidin
June 27th, 2008 | by admin |Synthesis and Antimicrobial Study of Novel 1-Aryl-2-oxo-indano[3,2-d]pyrido/pyrimido[1,2-b]pyrimidines.
A series of 2-(arylidene)-indan-1, 3-diones 1 were prepared by Knoevenagel reaction between indane-1,3-dione and the appropriate araldehydes. The alpha,beta-enones 1 have been used as a component of Michael addition with equimolar amounts of 2-aminopyridine/2-aminopyrimidine to give novel heterocyclic systems 4 and 5, respectively. They are reported here for the first time. The structures of the newly synthesized compounds were confirmed by IR, (1)H-NMR, (13)C-NMR, and elemental analysis. All compounds were screened for their antibacterial and antifungal activities. Some of them showed promising activities.
Sarvesh PK, Nizamuddin K.
Department of Chemistry, D. D. U. Gorakhpur University, Gorakhpur, India. Fax: +91 0551 2340459.