Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides.
April 12th, 2008 | by admin |Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides.
A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in-vitro cytotoxicity against various human cancer cell lines and their protein-kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound 6b is the most promising compound against the tested cancer cell lines; 6d and 6e showed moderate protein-kinase C inhibition. Structure-activity relationships are discussed based on the experimental data obtained.
Xu GQ, Zhang C, Zhang L, Zhou XL, Yang B, He QJ, Hu YZ.
ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. Fax: +86 571 8820-8460.