Optimization of sample transfer in two-dimensional microfluidic separation systems.
June 29th, 2008 | by admin |Optimization of sample transfer in two-dimensional microfluidic separation systems.
Multidimensional microfluidic separation systems combining a first dimension microchannel with an array of parallel second dimension microchannels can suffer from non-uniform sample transfer between the dimensions, sample leakage, and injection plug tailing within the second dimension array. These factors can significantly reduce overall two-dimensional separation performance. In this paper, numerical and analytical models reveal an optimized chip design which combines multidimensional backbiasing and an angled channel geometry to ensure leakage-free and uniform interdimensional sample transfer, while also minimizing injected sample plug lengths. The optimized design is validated experimentally using a multidimensional chip containing five second dimension channels.
Yang S, Liu J, Devoe DL.
Department of Mechanical Engineering, and Department of Bioengineering, University of Maryland, College Park, MD, USA. ddev@umd.edu.