Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.
July 3rd, 2008 | by admin |Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.
Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.
Cano A, Nieto MA.
Departamento de BioquÃmica UAM, Instituto de Investigaciones Biomédicas “Alberto Sols†CSIC-UAM Arturo Duperier 4, 28029 Madrid, Spain.