Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inh
May 1st, 2008 | by admin |Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry.
Mouse strains are well-characterized to exhibit differences in their physiological and behavioral responses to nicotine. This report examines the expression of the high-affinity nicotine binding receptor subunit, neuronal nicotinic receptor subunit alpha4 (nAChRalpha4), in the dorsal hippocampus of 27 inbred mouse strains. Multiple differences among mouse strains in the cellular expression of nAChRalpha4 between subregions of the hippocampal field are evident. Differences that we describe in the expression of nAChRalpha4 suggest mouse strains of diverse genetic origin could exhibit significant variation in how this receptor contributes to modulating intrahippocampal circuitry. These findings define a genetic frame-work in which the strain-specific responses to nicotine include underlying contributions by the varied anatomical context in which nAChRs are expressed. (c) 2008 Wiley-Liss, Inc.
Gahring LC, Rogers SW.
Salt Lake City VAâ€Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132.