Neuropeptide Y (NPY) Y2 receptors of rabbit kidney cortex are largely dimeric.
July 3rd, 2008 | by admin |Neuropeptide Y (NPY) Y2 receptors of rabbit kidney cortex are largely dimeric.
The neuropeptide Y (NPY) Y2 receptors and the pancreatic polypeptide Y4 receptors from rabbit kidney cortex are isolated largely as approximately 180 kDa complexes constituted of one receptor dimer and one G-protein heterotrimer, similar to NPY receptors expressed in the Chinese hamster ovary (CHO) cells. As expected, kidney and CHO cell Y2 dimers are converted into monomers by increasing concentrations of a selective agonist. Prevalence of dimeric Y2 receptors in the kidney could be related to low plasma levels of Y2 agonists, and possibly also to a relatively low concentration of Gi alpha subunits.
Estes AM, Wong YY, Parker MS, Sallee FR, Balasubramaniam A, Parker SL.
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.