Molecularly Imprinted Polymers for alpha-Tocopherol Delivery.
May 1st, 2008 | by admin |Molecularly Imprinted Polymers for alpha-Tocopherol Delivery.
Biomedical applications of antioxidants have increased dramatically since the link between human diseases and oxidative stress was established. This paper focuses on alpha -tocopherol and on the possibility of employing molecularly imprinted polymers as a controlled release device for alpha -tocopherol in gastrointestinal simulating fluids. Polymers were synthesized using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Considerable differences in recognition characteristics between imprinted and non-imprinted polymers, both in organic and in aqueous media, were observed. Imprinted polymers bound much more alpha -tocopherol and showed a controlled/sustained drug release capacity in gastrointestinal simulating fluids.
Puoci F, Cirillo G, Curcio M, Iemma F, Parisi OI, Castiglione M, Picci N.
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Arcavacata di Rende, Italy.