Molecular profiling in the diagnosis and treatment of high grade sarcomas.
May 1st, 2008 | by admin |Molecular profiling in the diagnosis and treatment of high grade sarcomas.
High-density microarrays are used to measure in a comprehensive manner large-scale (\”profile\”) gene expression patterns (when tumor RNA is tested) or gene copy number changes (when tumor genomic DNA is tested). Microarray-based studies are increasingly useful in addressing a wide variety of questions in sarcoma biology. This review includes a brief description of the microarray methodology and data analysis, followed by few examples of the recent applications of gene expression in the diagnosis, classification, and treatment of sarcomas.
Antonescu CR.
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.