Investigations Concerning the Correlation of COX-1 Inhibitory and Hydroxyl Radical Scavenging Activi
April 12th, 2008 | by admin |Investigations Concerning the Correlation of COX-1 Inhibitory and Hydroxyl Radical Scavenging Activity.
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.
Scholz M, Ulbrich H, Mattern A, Kramb JP, Kiefer W, Dannhardt G.
Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Johannes Gutenberg-University, Mainz, Germany. Fax: +49 6131 39-23062.