Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients foll
June 28th, 2008 | by admin |Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years.
Suppression of HIV replication using highly active antiretroviral therapy (HAART) might influence chemokine (C-C motif) receptor 5 expression on infected cells and therefore modulate the activity of chemokine (C-C motif) receptor 5 antagonists. Chemokine (C-C motif) receptor 5 expression was examined longitudinally in 26 HIV-infected adults who initiated HAART. Long-term suppression of plasma HIV-RNA did not significantly influence chemokine (C-C motif) receptor 5 expression on T lymphocytes. Therefore, the activity of chemokine (C-C motif) receptor 5 antagonists should not differ before and following HIV suppression on HAART.
Briz V, Poveda E, López M, González Mdel M, Soriano V, Benito JM.
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.