Hungry for blood vessels: linking metabolism and angiogenesis.
March 16th, 2008 | by admin |Hungry for blood vessels: linking metabolism and angiogenesis.
A new study by Arany et al. demonstrates that the metabolic master regulator peroxisome proliferator-activated receptor (PPARgamma) coactivator-1alpha (PGC-1alpha) can promote angiogenesis. These findings show that alterations in metabolic homeostasis are linked to angiogenesis, which raises exciting opportunities for novel proangiogenic and antiangiogenic therapies in various diseases.
Fraisl P, Baes M, Carmeliet P.
The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit Leuven, Leuven, B-3000, Belgium; Department of Transgene Technology and Gene Therapy, VIB, Leuven, B-3000, Belgium.