Heterogeneity and hypothesis testing in neuropsychiatric illness.
June 28th, 2008 | by admin |Heterogeneity and hypothesis testing in neuropsychiatric illness.
The confounding effects of heterogeneity in biological psychiatry and psychiatric genetics have been widely discussed in the literature. We suggest an approach in which heterogeneity may be put to use in hypothesis testing, and may find application in evaluation of the Crespi & Badcock (C&B) imprinting hypothesis. Here we consider three potential sources of etiologic subtypes for analysis.
Deutsch CK, Ludwig WW, McIlvane WJ.
Eunice Kennedy Shriver Center, University of Massachusetts Medical School (UMMS), Waltham, MA 02452, and Psychobiology Program, Harvard Medical School, Boston, MA 02115.