Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HS
June 27th, 2008 | by admin |Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs.
These studies were performed to determine the effect of AD-472, an attenuated human herpes simplex virus (HSV) type 2 or HSV-2 glycoprotein D (gD) when combined with an adjuvant, GPI-0100, a semi-synthetic Quillaja Saponin analog in a genital HSV-2 infection in guinea pigs. While animals immunized with either vaccine had reduced clinical disease, GPI-0100 only improved the efficacy of gD and did not affect the efficacy of the live vaccine. Neither vaccine had any therapeutic effect if administered 24h after viral infection.
Quenelle DC, Collins DJ, Rice TL, Prichard MN, Marciani DJ, Kern ER.
University of Alabama School of Medicine, Birmingham, AL, USA.