Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
June 27th, 2008 | by admin |Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.
FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228\’s novel mechanism of activation and HDAC inhibition.
Mays JR, Restituyo JA, Katzenberger RJ, Wassarman DA, Rajski SR.
School of Pharmacy, University of Wisconsin, Madison, WI 53705.