An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysi
June 27th, 2008 | by admin |An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysis.
CONCLUSION: We have shown that PTE chiral recognition is limited to organophosphorous esters having the chiral center on the phosphorous atoms, which is attacked with nucleophile, not having the chiral center on the other atoms of the leaving group. Therefore, PTE can be utilized for the synthesis of their chiral organophosphorous esters.
Ohuchi S, Nakamura H, Sligiura H, Narita M, Sode K.
Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, 184, Koganei, Tokyo, Japan.