A genome-based analysis of amino acid metabolism in the biotrophic plant pathogen Ustilago maydis.
June 28th, 2008 | by admin |A genome-based analysis of amino acid metabolism in the biotrophic plant pathogen Ustilago maydis.
Amino acid, nitrogen and sulfur metabolism play critical roles in the growth and development of fungal pathogens both in and outside of the host. The genome sequence of Ustilago maydis provides an opportunity for exploring these biochemical pathways by comparison to known gene sequences from other fungi. This approach was used to identify candidate genes for almost all enzymes required for amino acid biosynthesis and degradation, as well as the uptake and assimilation of nitrogen and sulfur. A number of differences were found between U. maydis and other basidiomycetes, and between basidiomycetes and ascomycetes in general. The use of genomics to explore central metabolic pathways may be of value in characterizing strict biotrophic pathogens like U. maydis that seem to derive a very limited set of nutrients from the host and thus must retain extensive biosynthetic capacity.
McCann MP, Snetselaar KM.
Biology Department, Saint Joseph’s University, 5600 City Avenue, Philadelphia, PA 19131, USA.